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Physical & Chemical properties

Partition coefficient

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Description of key information

log Pow =1.775 ± 0.008

Key value for chemical safety assessment

Log Kow (Log Pow):
1.775
at the temperature of:
22 °C

Additional information

The study was performed using a HPLC with a C18 column. Seven reference items with different retention times were used to produce a calibration curve, since retention time on hydrophobie columns and Pow are correlated .. First, a solution of the reference items was analysed with HPLC, then a solution of the test item, and finally again the solution with the reference items. Each analysis was performed three times, totalling to nine runs. For each reference item, the capacity factor K was calculated from the retention time of this urea and the retention time of the respective reference item. A calibration function (log K versus log Pow, linear fit) was determined using the literature va lues for Pow of the reference items and the retention times in the six determinations. The chromatogram of the test item gave one peak (mean retention time = 4.894min). With the help of the calibration function log K versus log Pow, the corresponding log Pow was determined as 1.775 ± 0.008 this value being the mean of three independent determinations.