Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

In vitro-test (Bacterial Reverse Mutation Test/Ames Test), OECD 471:

Five genetically manipulated strains of Salmonella were exposed to the test item both in the presence and in the absence of a metabolic activation system for 48 hours, using the plate incorporation method.None of the concentrations caused an increase in the number of revertant colonies in the tested strains.The test item neither showed any mutagenic effects nor any cytotoxicity in the Ames Test.


Short description of key information:
negative result in the Bacterial Reverse Mutation Test

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The test item needs not to be classified due to te negative in vitro-findings.