Registration Dossier
Registration Dossier
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EC number: 406-530-2 | CAS number: - MDI
Endpoint summary
Administrative data
Description of key information
The oral and dermal LD50 were determined to be >2000 mg/kg bodyweight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Additional information
In an acute oral toxicity test, performed according to OECD guideline 401 and GLP principles, five male and five female Wistar rats received a single dose of 2000 mg/kg bw. No deaths and no signs of toxicity were observed. The oral LD50 of MDI/CHA/ODA was therefore found to be > 2000 mg/kg bodyweight.
In an acute dermal toxicity test, performed according to OECD guideline 402 and GLP principles, five male and five female Wistar rats received a single (occlusive for 24 hours) dose of 2000 mg/kg bw. No deaths and no signs of toxicity were observed. The dermal LD50 of MDI/CHA/ODA was therefore found to be > 2000 mg/kg bodyweight.
Justification for classification or non-classification
Based on the available study results, MDI/CHA/ODA does not have to be classified for acute oral and acute dermal toxicity according to Regulation (EC) No 1272/2008.
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