Registration Dossier
Registration Dossier
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EC number: 255-255-2 | CAS number: 41198-08-7
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: literature value
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- NA
- GLP compliance:
- not specified
- Transformation products:
- not specified
- pH:
- 5
- Temp.:
- 20 °C
- DT50:
- 93 d
- Type:
- not specified
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 14.6 d
- Type:
- not specified
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 5.7 h
- Type:
- not specified
- Executive summary:
The 15th edition of The Pesticide Manual gives the following information on the stability of Profenofos:
Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions.
DT50 values calculated at 20 degree C give values of 93 days (pH5), 14.6 days (pH7) and 5.7 hours (pH9).
- Endpoint:
- hydrolysis
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- The hydrolysis of profenofos was estimated using the HYDROWIN program in EPISUITE based on the structure of profenofos which is inputted in the form of SMILES notation.
- GLP compliance:
- not specified
- Remarks:
- Not applicable
- Transformation products:
- not specified
- pH:
- 5
- DT50:
- 3.064 d
- pH:
- 7
- DT50:
- 2.98 d
- pH:
- 9
- DT50:
- 19.01 h
- pH:
- 10
- DT50:
- 2.477 h
- Conclusions:
- The half-life of profenofos in is estimated to be 2.98 days at pH 7, slightly longer in slightly acidic conditions (3.064 days at pH5) and much shorter in alkaline conditions (2.477 hours at pH 10).
- Executive summary:
The hydrolytic stability of profenofos was estimated using EPISUITE after inputting the structure in the form of SMILES notation.
Results show that degradation of profenofos is quicker in alkaline conditions than in neutral or slightly acidic conditions.
The half-life at pH7 is estimated to be 2.98 days.
Referenceopen allclose all
Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions.
Description of key information
Half-life of profenofos estimated with EPISUITE with a DT-50 of 2.98 days at pH 7.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 2.98 d
- at the temperature of:
- 20 °C
Additional information
The hydrolytic stability of profenofos was estimated using EPISUITE after inputting the structure in the form of SMILES notation.
Results show that degradation of profenofos is quicker in alkaline conditions than in neutral or slightly acidic conditions.
The half-life at pH 7 is estimated to be 2.98 days.
The 15th edition of The Pesticide Manual gives the following information on the stability of Profenofos: Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions. DT50 values calculated at 20 degree C give values of 93 days (pH 5), 14.6 days (pH 7) and 5.7 hours (pH 9).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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