Registration Dossier
Registration Dossier
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EC number: 941-221-0 | CAS number: 203929-12-8
Endpoint summary
Administrative data
Description of key information
An acute inhalation toxicity was conducted on IOFH. The result of the study was:
The rat inhalation LC50 is greater than 431.5 ppm (6.25 mg/L, vapor) when tested according to OECD 403.
Key value for chemical safety assessment
Additional information
The acute inhalation toxicity of the test article (Clear and colorless to pale pink liquid, Purity 98.2%, Lot: IOFH-AH221-ANL1200052) was evaluated in Sprague Dawley rats. The study was not conducted under GLP conditions. The test method was based OECD Guideline 403 (1981). The test article was administered as a vapor. Male rats (3/group) were exposed, whole body, to the test article at 91 ppm (equivalent dose 1.32 mg/L) or 863 ppm (equivalent dose 12.49 mg/L) and for a single, 1 hour exposure. Clinical observations (for 2 hours after exposure and daily thereafter) and body weights (prior to exposure and on Days 8 and 15) were recorded. Limited necropsy was performed on all animals on Day 15, no organs or tissues were collected. All animals survived to scheduled necropsy. Animals in the 863 ppm group exhibited slightly increased activity, slight ataxia, and in one animal occasional gasping during exposure. Animals in the 91 ppm group exhibited slightly increased respiration rates during exposure. Clinical signs post-exposure were normal in all animals. Body weight gains were normal in all animals. No gross lesions were observed in any animals at necropsy. Based on the results of the study, the 4-hour equivalent LC50 of the test article is great than 431.5 ppm (6.25 mg/L, vapor).
Justification for classification or non-classification
The test article meets the CLP classification criteria for Acute Toxicity Category 4.
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