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EC number: 434-800-1 | CAS number: 121776-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Feb 28, 1990 to March 14, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- yes (Relative humidity was outside the range specified in the guideline but it did not impact the results outcome.)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: Limit test
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 434-800-1
- EC Name:
- -
- Cas Number:
- 121776-33-8
- Molecular formula:
- C11H13CL2NO3
- IUPAC Name:
- 2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one
- Reference substance name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- IUPAC Name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): MON 13900
- Physical state: Brown particles (powder)
- Lot/batch No.: DAY 8912-137OT
- Expiration date of the lot/batch: December, 1993 (estimated)
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Males and female young adult Sprague Dawley rats, obtained from Charles Rivers Laboratories, Inc., Raleigh, North Carolina, were used for the study. The animals were individually housed in suspended stainless steel cages in an environment-controlled room with a 12-h light/dark cycle. Agway Prolab rodent feed arid water was provided to each animal ad libitum. The rats were individually identified using metal ear tags and cage cards. All animals were allowed to acclimate to the laboratory environment for a minimum of 5 d prior to initiation of the study.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was administered to one group of five male and five female rats by a single dermal dose at a level of 5000 mg/kg bw. On the day prior to dosing, the fur was clipped from the dorsal area of the trunk of each animal using small animal clippers. The clipped area measured
approx 10% of the animal’s total body surface. Care was taken during clipping to avoid accidental abrasion to the skin. On the following day, 5 male and 5 female rats were weighed and the test substance was applied uniformly over the clipped area at the appropriate dose. Each animal’s dose was contained at the area of application using an 8 ply gauze dressing covered with plastic wrap. A stockinette sleeve was positioned around the trunk of each animal and secured in place using tape. After an exposure period of 24 h, the stockinette sleeve, plastic wrap and gauze dressing were removed. The exposure site on each animal was rinsed with distilled water to remove residual test substance. No attempt was made to quantitate the amount of nonabsorbed test substance. Following dosing, the animals were observed frequently for clinical signs on the day of dosing and once daily thereafter for the duration of the study. Mortality checks were performed twice daily, in the morning and afternoon. Individual body weights were determined and recorded on Days 1, 8 and 15. All animals were subjected to a gross necropsy examination at the time of sacrifice (CO2 asphyxiation). - Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg/ bw
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- not required
- Details on study design:
- Following dosing, the animals were observed frequently for clinical signs on the day of dosing and once daily thereafter for the duration of the
study. Mortality checks were performed twice daily, in the morning and afternoon. Individual body weights were determined and recorded on Days 1, 8 and 15. All animals were subjected to a gross necropsy examination at the time of sacrifice (CO2 asphyxiation).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No apparent test substance related clinical signs were observed.
- Gross pathology:
- No remarkable gross internal findings were observed in the animals at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the acute dermal LD50 of MON 13900 for rats was estimated to be greater than 5,000 mg/kg bw.
- Executive summary:
A study was conducted to evaluate the acute dermal toxicity of MON 13900 in rats according to the EPA OPP 81-2 Guideline in compliance with GLP.
A group of male and female rats received a topical application of the test substance at 5,000 mg/kg bw. Following dosing, the rats were observed daily and weighed weekly. No mortality or apparent test substance related clinical signs were observed. Mean bodyweight gain was acceptable. No remarkable gross internal findings were observed in the animals at necropsy.
Under the test conditions, the acute dermal LD50 of the test substance for male and female rats was estimated to be greater than 5,000 mg/kg bw.
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