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Diss Factsheets
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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Salicylazosulfapyridine (SASP) can increase the incidence of tumor. But available data is insufficient to conclude the carcinogen potential of sulfapyridine.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, Salicylazosulfapyridine (SASP)can cause thecancer incidence. However, it is inclusive to make the classification for sulfapyridine.
Additional information
Only one study performed by MICHAEL J. IATROPOULOS, et al. 1996, was available to determine the Carcinogenicity ofSASPwithF344/N ratsandB6C3F1 hybrid mice.
In AL-fed rats, urinary bladder papillomas were increased from 0 to 12 % in the high dose (337.5 mg/kg) SASP groups with concomitant reduction (from 26 % to 6 %) of mononuclear cell leukemia (MCL). In the WM (high dose SASP) groups, the neoplastic changes were the same, i.e. the incidence increase (in papillomas) was 12 % and the incidence in MCL was 6 %. In the DR (high dose SASP) groups, no papillomas were present, and the incidence of MCL was 4 % compared to 22 % in the controls.Moreover,SASP caused intraluminal bladder changes in the rats (especially males) consisting of chronic urothelial stimulation, concretions, hyperplasia which resulted in neoplasia.
In the case of mice, SASPcan increase mouse liver tumors under ad libitum (AL) feeding conditions, while under a feed restriction (FR) regimen, these tumors were not increased.
Based on the results of the existing study,an increased incidence of liver tumor in mice andurinary bladder papillomasin rats in both sexes, conducted in a well-conducted study, provide the sufficient evidence ofa causal relationshipbetween the substance and the increased incidence oftumor. Therefore, SASP can cause the cancer incidence.
Carcinogenicity: via oral route (target organ): digestive: liver; urogenital: urinary bladder
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