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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a publication result with a scientific method
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- GLP compliance:
- no
- Type of study / information:
- Three 60-L instantaneous samples of municipal wastewater were collected in plastic containers lined with polyethylene bags in the morning (10-11 a.m.) for drugs analysis. The samples were kept at 4 °C in the dark during transport.
Primary cultures of rainbow trout (O. mykiss) hepatocytes were freshly prepared and plated at a density of 0.5 million/2 mL of culture medium according to a citrate/ albumin perfusion methodology (Gagne and Blaise, 2001). Fish were sexually immature at 6 months to 1 year of age and three to four livers were pooled to alleviate interindividual variability. Rainbow trout were collected from a local hatchery and acclimatized for at least 1 month in 300-L tanks filled with aerated, UV- treated, and charcoal-filtered tap water at 15 °C. They were fed with commercial trout feed three times a week.
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Details on test material:
- no data
Constituent 1
Results and discussion
Any other information on results incl. tables
In vitro production of oxidative metabolism in trout liver microsomes by Sulfapyridine (100µM) in the municipal effluent: 15 (NADPH oxidation rate); 5.25 (Lipid peroxidation); 0.27 (0,N,S/CH ratio)
Applicant's summary and conclusion
- Conclusions:
- The result show that sulfapyridine accelerated the rate of NADPH oxidation in the presence of microsomes and increased LPO in microsomal membranes.
- Executive summary:
The purpose of this study was to examine the cytotoxic and oxidative effects of these products and other wastewater-related products in primary cultures of rainbow trout hepatocytes. The redox activity of various PPCPs in trout (Oncorhynchus mykiss) liver microsomes was investigated in vitro by tracking the rate of oxidation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and the formation oflipid peroxidation (LPO) after a 60-min incubation period. In addition, primary cultures of rainbow trout hepatocytes were exposed to various drugs identified in the municipal effluent for 48 h at 15 °C. The result show thatsulfapyridineaccelerated the rate of NADPH oxidation in the presence of microsomes and increased LPO in microsomal membranes.
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