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EC number: 252-744-2
CAS number: 35836-73-8
Retention times and capacity factors
The retention times of the reference items
are presented in the following table.
log Pow / log k
The calculated values for the test item are
presented in the following table.
log Pow is calculated using the
regression equation obtained from the reference items.
log Pow = (log k + 1.072) / 0.382
Results obtained with another HPLC Column
The retention times capacity factors of the
reference items obtained with a different C18 bonding are presented in
the table below.
The linear regression of the plot log k
versus log Pow gives the following equation:
log k = (0.424 x log Pow) - 0.919
with a coefficient of determination r2
The retention time of the test item was 7.97
min, corresponding to a log k of 0.42. According to the previous
equation, the log Pow can be estimated to 3.16 with this
This result is not significantly different
from the one obtained previously (3.09). It can be concluded that a
change in the C18 silica bonding chemistry has not significant effects
on log Pow results.
purpose of the study was to determine the partition coefficient
n-octanol / water (log Pow) of NOPOL using HPLC (High
Performance Liquid Chromatography).
The study was performed using the HPLC
method. Eight reference items with different retention times were used
to produce the calibration curve. They were chosen in relation to the
expected retention time of the test item. For each reference item, two
determinations were performed. The capacity factor k was calculated from
the retention time of acetone (dead time) and the retention time of the
respective reference item. A calibration function (log k versus log Pow,
linear fit) was determined based on literature values of Pow
for the reference items.
Using the calibration function log k versus
log Pow, the following log Pow was determined for
Mean retention time: 5.89 min
log Pow: 3.09 + 0.01
This value is the mean + standard
deviation of three independant determinations.
The partition coefficient was determined by the HPLC method.The partition coefficient log Pow of nopyl acetate is 3.09 ± 0.01.
Key study conducted by the High
Performance Liquid Chromatographic method according to OECD 117
Guideline and EU Method A8 without any deviation. Therefore, this value
can be used as key value.
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