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EC number: 252-744-2
CAS number: 35836-73-8
an acute oral toxicity study performed similarly to Guideline OECD 401,
groups (10 /dose) of rats were given a single oral dose of Nopol at 340,
670, 1310, 2560 and 5000 mg/kg bw. Animals were then observed for
mortality and clinical signs for 14 days and all survivors were
sacrificed for macroscopic examination.
lethargy and flaccid rats were observed. Deaths occurred overnight to 14
days following administration of the test item. 1/10, 3/10, 7/10, 10/10
and 10/10 animals died at 340,
670, 1310, 2560 and 5000 mg/kg
this study, the oral LD50 of the test item was 890 mg/kg bw.
The oral LD50 for Nopol was evaluated to 890
mg/kg bw in rats which is higher than 300 mg/kg bw and lower than 2000
According to Regulation EC No. 1272/2008 and
according to GHS criteria, the test item has to be classified in
category 4. The signal word “Warning” and hazard statement H302 “Harmful
is swallowed” are required.
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