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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
BASF-Test: Animals were treated for 1, 5, and 15 min using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5 and 15 min) the skin was washed with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 h and 72 h from the raw data were taken into account.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propionyl chloride
EC Number:
201-170-0
EC Name:
Propionyl chloride
Cas Number:
79-03-8
Molecular formula:
C3H5ClO
IUPAC Name:
propanoyl chloride
Details on test material:
- Name of test material (as cited in study report): Propionsaurechlorid
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
1, 5 and 15 min
Observation period:
8 d
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm (patch test)

REMOVAL OF TEST SUBSTANCE:
- After the application time, the skin was washed with water.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: erythema score for 1 min exposure, score for the border of the application site
Basis:
animal: #1 and #2
Time point:
other: 24 h-8 d
Score:
2 - 3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: necrosis (edema scoring not possible)
Irritation parameter:
other: erythema score for 5 min exposure, score for the border of the application site
Basis:
animal: #1 and #2
Time point:
other: 24 h-8 d
Score:
2 - 3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: severe necrosis (edema scoring not possible)
Irritation parameter:
other: erythema score for 15 min exposure, score for the border of the application site
Basis:
animal: #1 and #2
Time point:
other: 24 h-8 d
Score:
2 - 3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: severe necrosis (edema scoring not possible)
Irritant / corrosive response data:
After 24 hours and 8 days, (severe) necrosis was observed after 1, 5 and 15 min of exposure and redness was observed at the edges (both animals). The study was not performed for the 20 hours exposure duration, due to the severe effects observed after 1, 5 and 15 minutes exposure.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information