Registration Dossier
Registration Dossier
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EC number: 201-170-0 | CAS number: 79-03-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound propionyl chloride: In contact with water the substance will hydrolyse rapidly.
Hydrolysis product propionic acid: The substance is readily biodegradable.
Key value for chemical safety assessment
Additional information
Parent compound: Based on a weight-of-evidence approach, propionyl chloride is determined to hydrolyse rapidly to propionic acid (CAS 79 -09 -4) and HCl. This is confirmed by read across to the analogue substances stearoyl chloride (CAS 112 -76 -5), 2 -ethylhexanoyl chloride (CAS 760 -67 -8), pivaloyl chloride (CAS 3282 -30 -2), neodecanoyl chloride (CAS 40292 -82 -8) and nonanyl chloride (CAS 764 -85 -2). All these compounds hydrolyse rapidly (<< 24 h) to the corresponding acid and HCl.
The measured data are supported by HYDROWIN v2.00 data (EPI Suite v4.10) which indicate that acyl halides usually have hydrolytic half-lives of less than 10 minutes.
Hydrolysis products: According to Lyman et al. (1990) propionic acid is not expected to undergo hydrolysis in the environment, due to the lack of hydrolyzable functional groups. Furthermore propionic acid is readily biodegradable (cf. chapter 5.2). In Annex VIII of Regulation (EC) No 1907/2006, it is laid down that the study on hydrolysis does not need to be conducted if the substance is readily biodegradable. Therefore, no test on hydrolysis is performed. Propionic acid is readily biodegradable (weight of evidence approach, see Ch. 5.2.1), while HCl is inorganic.
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