Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-170-0 | CAS number: 79-03-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound propionyl chloride: No data available.
Hydrolysis product propionic acid/calcium proprionate: The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations after pH-adjustment.
Hydrolysis product HCl: No data available.
Key value for chemical safety assessment
Additional information
Parent compound propionyl chloride:
Propionyl chloride (CAS 79-03-8) rapidly decomposes in water and forms HCl (CAS 7647-01-0) and propionic acid (CAS 79-09-4). No data are available for propionyl chloride, therefore the toxicity to microorganisms is assessed via read across to the hydrolysis product propionic acid and the structurally similar substances calcium propionate (CAS 4075-81-4). The analogous substance was chosen in order to avoid the pH dependent effect of pure propionic acid solution.
Propionic acid and calcium propionate:
The toxicity of propionic acid to the test organismPseudomonas putida was studied according to German Industrial Standard DIN 38412 part 8. The 17-h EC10 and EC50 were determined to be 44 mg/L and 59.6 mg/L, respectively (nominal, not neutralized; BASF, 1989; report no. 9/1103/87).
Calcium propionate was also tested according to German Industrial Standard DIN 38412, part 8. The 17-h EC10 and EC50 were determined to be 347 mg/L and 506 mg/L, respectively (nominal; BASF, 1989; report no. 9/1540/88). The comparison of both studies shows that the results are pH-dependent. A short-term respiration inhibition test according to ISO 8192 was performed with calcium propionate using domestic activated sludge the 30 min EC20 was determined to be 500 to 1040 mg/L (BASF AG, 1989; report no. 01.0689).
It can be concluded that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations after pH-adjustment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
