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EC number: 232-140-5
CAS number: 7789-00-6
Concentrations of 0.5% and below of aqueous potassium dichromate have
been reported to elicit positive responses in patch testing studies. In
one study, a minimum (10% reacting) elicitation concentration of 0.09 µg
Cr(VI)/cm2 was calculated after 54 Cr(VI)-sensitive volunteers were
exposed to potassium dichromate.
Allergic contact dermatitis (skin sensitisation) resulting from
occupational exposure to water soluble Cr (VI) compounds is commonly
encountered in a number of different groups. The EU RAR has reviewed a
number of published reports of patch testing in Cr (VI) sensitised
humans; the studies report minimum eliciting concentrations as low as
0.09 ug Cr (VI) /cm2. The majority of reported studies were performed
using aqueous solutions of sodium or potassium dichromate; while similar
effects can be assumed for other water-soluble Cr (VI) compounds, a
similar concentration-response relationship cannot be assumed as this
will also be influenced by the extent of dermal penetration.
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