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EC number: 232-140-5
CAS number: 7789-00-6
In terms of human experience, direct accidental contact with very
acidic or high temperature solutions of highly water-soluble Cr (VI)
compounds has resulted in severe burns to human skin. It is not clear
from the available reports whether intact skin is damaged by single
contact with neutral solutions of such compounds. In one patch test
study, some volunteers responded to 0.5% aqueous potassium dichromate
with mild irritation especially around hair follicles. In workers
regularly exposed to highly water-soluble Cr (VI) in solution, chrome
ulcers develop after some initial damage to the skin. This has been
described for dye workers handling sodium or potassium dichromate
solutions and frequently in exposed workers in the chromate production
and chrome plating industries. The severity of the ulcer depends upon
the frequency and duration of skin contamination. Small papules
develop initially, progressing to an ulcer which penetrates gradually
to deeper skin layers. Typically, chrome ulcers have a hard circular
periphery and a cavity leading to a base covered with exudate or a
The EU RAR concludes, based on reports of accidental occupational
exposure, that the highly water soluble Cr (VI) compounds are skin
irritants. Chromium (VI) trioxide is corrosive as a consequence of its
low pH and the development of 'chrome ulcers' in workers repeatedly
exposed to other salts also indicate the potential for skin corrosivity.
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