Registration Dossier
Registration Dossier
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EC number: 410-400-0 | CAS number: 88671-89-0 SYSTHANE TECHNICAL
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption, Distribution, Excretion and Metabolism of Myclobutanil was extensively studied and evaluated (EFSA Journal 2010;8(10):1682).
In rats and mice, myclobutanil is rapidly absorbed; comparing urinary excretion after oral and intravenous administration of a single low dose suggests that bioavailability is important in rats, reaching 100%. Therefore, no correction for oral absorption is required. The dermal absorption values based on in vitro and in vivo studies are 25% for the concentrate and 15% for the dilution.
Myclobutanil is widely distributed with high levels detected in liver, kidney, adrealsand intestine. No significant accumulation was seen after 96 hours from administration.
Metabolism is extensive; low levels of unchanged parent compound are detected in urine and faeces. There is no cleavage of the molecule and the major metabolic pathway involves oxidation of the butyl side chain. Most of an oral dose is eliminated in urine and faeces within 24 to 48 hours.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
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