Registration Dossier
Registration Dossier
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EC number: 271-766-3 | CAS number: 68607-67-0
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Surrogate substance used. This is the starting amine that appears to be more hazardous to Daphnia than 'Reaction products of C11-14 tert-alkylamine and formaldehyde' and can therefore be used for assessment.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report N,N-Dimethyldodecylamine
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- OECD SIDS N,N-DIMETHYLDODECYLAMINE, 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- Molecular formula:
- C14H31N
- IUPAC Name:
- C12-Dimethyldodecylamine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- Natural river water used
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.036 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC10
- Effect conc.:
- ca. 0.11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Applicant's summary and conclusion
- Conclusions:
- A dose-related effect was observed with a NOEC establised at ca 0.1 mg/l.
When compared with the short term test, the effect levels are similar (in fact, short term effect recording an EC50 of 0.83 mg/lg based on analysis) implying that the toxic effects are not accumulative.
In view of the similarities in the chemisty between these substances and the siilarity in properties and actue effects, it can be assumed that Reaction products of C11-14 tert-alkylamine and formaldehyde will have a NOAEC to Daphnia in the range of 0.1 - 1 mg/l for purposes of classification
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