Registration Dossier
Registration Dossier
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EC number: 258-007-1 | CAS number: 52558-73-3
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Reference
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the toxicity to sediment organisms.Key value for chemical safety assessment
Additional information
According to the Guidance on information requirements and chemical safety assessment, R.7b (ECHA, 2017) no sediment testing is necessary if the PEC/PNEC ratio is below one. The environmental exposure assessment for N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) indicates no risk for the sediment compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information).
Furthermore, due to the high water solubility of the substance (0.9 g/L at 25 °C, pH 5) and the log Koc of 2.45-4.32 (Franco & Trapp, 2008) indicating low to moderate potential for adsorption of the substance to sediment particles. However, the substance is determined to be readily biodegradable and according to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2017). Therefore, this substance has a low potential for persistence and chronic exposure of sediment organisms is unlikely.
In addition, the substance has a low potential for bioaccumulation based on a log D of 1.52 at pH 7 and 0.63 at pH 9 (SPARC v4.6) and estimated log BCF values ranging from 10-306.9 L/kg (BCFBAF v3.01). These BCF-values are well below 2000 L/kg, the cut-off value defining a substance as Bioaccumulative (B) according to Annex XIII of Regulation (EC) No. 1907/2006. Furthermore, available data on the metabolism and excretion of sarcosinates in mammals clearly indicate extensive and rapid excretion, and reduced bioaccumulation potential. Thus, the substance is not expected to bioaccumulate in aquatic species.
Thus, taking all these information into account, no further long-term test with sediment organism is proposed for N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3).
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