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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

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Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR model.
Justification for type of information:
QSAR prediction.
Principles of method if other than guideline:
Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
other: calculation
Water / sediment media type:
natural water: freshwater
Details on estimation of bioconcentration:
BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Pow of: 5.08 (estimated, KOWWIN v.1.68)
Type:
BCF
Value:
306.9 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
Type:
BAF
Value:
308 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR model.
Justification for type of information:
QSAR prediction.
Principles of method if other than guideline:
Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
other: calculation
Water / sediment media type:
natural water: freshwater
Details on estimation of bioconcentration:
BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Pow of: 5.08 (estimated, KOWWIN v.1.68)
Type:
BCF
Value:
10 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Regression based estimate

Description of key information

BCF (regression method):    10 L/kg  (BCFBAF 3.01)
BCF (Arnot-Gobas method):    306.9 L/kg  (BCFBAF 3.01)
BAF (Arnot-Gobas method):    308 L/kg  (BCFBAF 3.01)

Key value for chemical safety assessment

Additional information

N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) has a low potential for bioaccumulation at environmentally relevant pH based on its log D values (used for ionisable substances instead of log Kow) of 1.52 at pH 7 and 0.63 at pH 9 (SPARC v4.6), indicating low lipophilicity at the environmentally relevant pH of 7 to 9. According to REACh regulation (EC) No 1907/2006, substances with log Kow ≤ 3.0 have a low potential for bioaccumulation. Thus, further testing is not required in accordance with Annex IX, column 2, 9.3.2. of Regulation (EC) No. 1907/2006.

Furthermore, the predicted BCF values also indicate that the potential for bioconcentration in aquatic organisms is low. The estimated BCF values are 10 – 306.9 L/kg wet-wt (BCFBAF v3.01), which are well below the cut-off value of 2000 L/kg wet-wt for bioaccumulative and 5000 L/kg wet-wt for very bioaccumulative substances, as laid down by section 1 of Annex XIII of REACH Regulation (EC) No. 1907/2006. In addition, toxicokinetic considerations with regard to absorption, distribution, metabolisation and excretion of the substance provide further evidence for a low potential for bioaccumulation. While absorption after oral uptake is considered likely, systemic distribution, accumulation and metabolisation of the substance is not anticipated and urinary excretion is expected to be an important and rapid excretion pathway based on experimental mammalian studies with structurally similar substances (for further details, please refer to the toxicokinetic statement in IUCLID section 7.1).

Moreover, N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) is readily biodegradable. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2016). Therefore, only low concentrations of the substance are likely to be released into the environment through conventional STPs, if at all, and whatever fraction is released will not persist. Thus, exposure of aquatic organisms and bioavailability in the environment is expected to be low.

 

In conclusion, N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) is expected to have a low potential for bioaccumulation.