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EC number: 258-007-1 | CAS number: 52558-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 30364-51-3, Harlan, 2013, D. magna, 48 h
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 5.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, CAS 30364-51-3, Harlan, 2013, D. magna, 48 h
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.9 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% Confidence limits: 3.4 - 5.1 mg/L
- Remarks:
- Source: RA-A, CAS 30364-51-3, Harlan, 2013, D. magna, 48 h
- Conclusions:
- The effect concentration for short-term toxicity to aquatic invertebrates retained as key value is an EC50 (48 h) of 4.1 mg/L based on experimental data from a structurally and chemically closely related source substance (geom. mean measured, OECD 202, D. magna); read-across
Reference
Description of key information
EC50 (48 h) = 2.9 mg/L for Daphnia magna (OECD 202, arith. mean meas.); read-across
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.9 mg/L
Additional information
No studies investigating the short-term toxicity to aquatic invertebrates are available for N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3). Therefore, in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3), the respective sodium salt, was conducted.
This read-across approach is in compliance with Annex XI, 1.5, of Regulation (EC) No 1907/2006. The chemical properties of the target and source substance are similar due to the structural similarities, i.e., sarcosine head group and the hydrocarbon tail. In addition, at physiological pH values (above 6) the target substance is expected to be in the anionic form, as are the source substance. As a result, the chemistry of the target and source substance, in solution (above pH 6), are expected to be similar. Thus, the source substance is considered suitable representative for the assessment of the aquatic toxicity of the target substance. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
The study conducted with the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was performed according to OECD Guideline 202 and GLP. Daphnia magna was exposed to nominal, filtered test concentrations of 1, 3.2, 10, 32 and 100 % v/v saturated solution for 48 h. Analytical measurements of test concentrations using HPLC-MS resulted in significantly lower measured concentrations (1.7 mg/L and 5.1 mg/L) with respect to nominal concentrations (32 and 100 % v/v saturated solution). Thus, the effect concentrations were based on the arithmetic mean measured concentrations. Effects on daphnids mobility were only observed at the highest concentration (5.1 mg/L, measured), leading to an EC50 (48 h) of 2.9 mg/L (arith. mean measured).
Based on the available results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), which is characterized by a similar chemistry, it can be concluded that the target substance N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) will exhibit comparable effects on aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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