Registration Dossier
Registration Dossier
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EC number: 258-007-1 | CAS number: 52558-73-3
Endpoint summary
Administrative data
Description of key information
Additional information
No ecotoxicological data are available for the aquatic toxicity of N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3). Therefore, read-across to the structurally related source substances Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3), Sodium N-lauroylsarcosinate (CAS 137-16-6) and N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) was conducted in compliance with Annex XI, 1.5, of Regulation (EC) No 1907/2006 for the short-term toxicity to fish, the short-term toxicity to aquatic invertebrates, the toxicity to aquatic algae and the toxicity to microorganisms in order to fulfil the standard information requirements according to Annex IX of Regulation (EC) No 1907/2006. The common structural features of the target and source substances are a sarcosine head group and a hydrocarbon tail. Based on these structural similarities, their chemical properties and behaviors are expected to be similar. Both the target and source substances are expected to be present in the anionic form at physiological pH and are thus expected to have similar chemistry in solution at pH values above 6. Thus, the source substances are considered suitable representatives for the assessment of the aquatic toxicity of the target substance. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
The short-term toxicity to fish was assessed for the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) in a GLP-study according to OECD 236, which resulted in an LC50 (96 h) of 4.256 mg a.i./L (meas. geom. mean).
The short-term toxicity to aquatic invertebrates was assessed for the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) in a GLP-study according to OECD 202. The lowest reported effect concentration for immobilization is an EC50 (48 h) of 2.9 mg/L (arith. mean measured).
The toxicity to aquatic algae was tested in a GLP-study according to OECD 201 for the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3). The reported effect values for inhibition of growth are an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).
The toxicity to microorganisms was assessed in three studies according to OECD 209 for the source substances Sodium N-lauroylsarcosinate (CAS 137-16-6) and N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) with activated sludge as inoculum. The reported effect values for inhibition of the respiration of activated sludge microorganisms were an EC50 (3 h) of > 100 mg/L and a NOEC (3 h) of 10 mg/L (nominal).
Based on the structural similarities between the target and source substances and their similar chemistry in solution, the target substance is expected to exhibit a similar ecotoxicological profile as the source substances. The data compiled in the data matrix of the analogue justification in IUCLID section 13 is considered reliable and shows a consistent pattern of results, thus supporting the read-across approach.
Therefore, aquatic invertebrates represent the most sensitive trophic for the aquatic toxicity of N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) based on the available data.
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