Registration Dossier
Registration Dossier
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EC number: 258-081-5 | CAS number: 52663-87-3
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
A close analogue of the registered substance is not acutely toxic via the oral or dermal routes (LD50 > 2000 mg/kg) andoral administration of the same analogue to rats by gavage, at dose levels of 50, 300 and 1000 mg/kg bw/day in a 28-day repeated dose study (OECD 407) was well tolerated and the NOAEL was reported as 1000 mg/kg bw/day (equivalent to 404 mg a.i./kg bw/day). Similar results were reported with the same analogue test item when doses of 43, 160 and 600 mg a.i./kg bw/day were administered to rats during a combined repeated dose toxicity study with reproduction/developmental toxicity screening (OECD 422) and the NOAEL was reported as 600 mg a.i./kg bw/day.Moreover, no evidence of skin irritation/corrosion, serious eye damage/irritation or skin sensitisation was found during performance of appropriate studies.In the absence of systemic or local effects by the oral or dermal route DNELs could not be derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
A close analogue of the registered substance is not acutely toxic via the oral or dermal routes (LD50 > 2000 mg/kg) andoral administration of the same analogue to rats by gavage, at dose levels of 50, 300 and 1000 mg/kg bw/day in a 28-day repeated dose study (OECD 407) was well tolerated and the NOAEL was reported as 1000 mg/kg bw/day (equivalent to 404 mg a.i./kg bw/day). Similar results were reported with the same analogue test item when doses of 43, 160 and 600 mg a.i./kg bw/day were administered to rats during a combined repeated dose toxicity study with reproduction/developmental toxicity screening (OECD 422) and the NOAEL was reported as 600 mg a.i./kg bw/day.Moreover, no evidence of skin irritation/corrosion, serious eye damage/irritation or skin sensitisation was found during performance of appropriate studies. In the absence of systemic or local effects by the oral or dermal route DNELs could not be derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
