Registration Dossier
Registration Dossier
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EC number: 807-365-2 | CAS number: 127961-54-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov. 18, 2013 - Jan. 3, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Note: result is based on detection limit.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 2.11
- Temp.:
- 21.6 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- No test substance was detected in the water phase. The Log Pow was calculated from the detection limit of the water solubility and the extraction factor of 5 mL hexane / 30 mL water. This gave a concentration limit of the test substance in water as <15.1 mg/L, which was used to calculate the Pow.
- Conclusions:
- The log Pow of the test substance is >2.11.
- Executive summary:
The water/octanol partition coefficient was determined in an OECD Guideline 107 study. The test substance was not detectable in the water phase due to its low solubility. The partition coefficient was then estimated based on the detection limit of the substance in water of 15.1 mg/L. The log Pow is >2.11.
Reference
Description of key information
Log Kow is > 2.11 at 21.6 ºC (OECD 107, shake-flask method).
Estimated Log Kow > 10 (QSAR, KOWWIN v1.68).
Key value for chemical safety assessment
Additional information
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