Registration Dossier
Registration Dossier
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EC number: 231-323-7 | CAS number: 7492-66-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs on Citral diethyl acetal
- Author:
- D. L. J. Opdyke
- Year:
- 1 983
- Bibliographic source:
- Food and Chemical Toxicology, Volume 21, Issue 5, October 1983, Page 667
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the skin irritation potential of citral diethyl acetal in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- EC Number:
- 231-323-7
- EC Name:
- 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Cas Number:
- 7492-66-2
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Test material form:
- liquid
- Details on test material:
- - Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Common name: Citral diethyl acetal
- Molecular formula : C14H26O2
- Molecular weight : 226.357 g/mol
- Smiles notation : C(\C=C(\CC\C=C(/C)C)C)(OCC)OCC
- InChl : 1S/C14H26O2/c1-6-15-14(16-7-2)11-13(5)10-8-9-12(3)4/h9,11,14H,6-8,10H2,1-5H3/b13-11+
- Substance type:Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Common name: Citral diethyl acetal
- Molecular formula: C14H26O2
- Molecular weight: 226.357 g/mol
- Smiles notation: C(\C=C(\CC\C=C(/C)C)C)(OCC)OCC
- InChl: 1S/C14H26O2/c1-6-15-14(16-7-2)11-13(5)10-8-9-12(3)4/h9,11,14H,6-8,10H2,1-5H3/b13-11+
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- full strenth, undiluted test chemical
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderately irritating to rabbit skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Citral diethyl acetal was moderately irritating to rabbit skin after 24 hours exposure.
- Executive summary:
A study was performed to assess the dermal irritation potential of citral diethyl acetal in rabbits.Undiluted citral diethyl acetal was applied under occlusion to intact and abraded skin of rabbits. The rabbits were observed for signs of irritation for 24 hours.Citral diethyl acetal was moderately irritating to rabbit skin after 24 hours exposure.
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