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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from WHO report

Data source

Reference
Reference Type:
publication
Title:
SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
Author:
WHO FOOD ADDITIVES SERIES: 48
Year:
2002
Bibliographic source:
Fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) World Health Organization, Geneva, 2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute toxicity test was performed on male rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-diethoxy-3,7-dimethylocta-2,6-diene
EC Number:
231-323-7
EC Name:
1,1-diethoxy-3,7-dimethylocta-2,6-diene
Cas Number:
7492-66-2
Molecular formula:
C14H26O2
IUPAC Name:
1,1-diethoxy-3,7-dimethylocta-2,6-diene
Details on test material:
- Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic
- Impurities (identity and concentrations): No data
Specific details on test material used for the study:
- Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated male rat
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally.
Executive summary:

In a Acute toxicity test, male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 5000 mg/kg bw orally. No mortality was observed in treated male rat at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw when male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally.