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EC number: 807-889-1
CAS number: 1255203-42-9
An assessment of acute oral toxicity with D-C16 in the rat (Acute Toxic
Class Method) was carried out based on the guidelines described in: OECD
No.423 (2001) "Acute Oral Toxicity, Acute Toxic Class Method" Commission
Regulation (EC) No 440/2008, B1 tris: "Acute Oral Toxicity, Acute Toxic
Class Method" EPA, OPPTS 870.1100 (2002), "Acute Oral Toxicity" JMAFF
Guidelines (2000), including the most recent revisions.
D-C16 was administered by oral gavage to two subsequent groups of three
female Wistar rats at 2000 mg/kg body weight. Animals were subjected to
daily observations and weekly determination of body weight. Macroscopic
examination was performed after terminal sacrifice (Day 15). No
mortality occurred. Hunched posture and/or piloerection were noted for
the animals on Days 1, 2 and/or 5. The body weight gain shown by the
animals over the study period was considered to be normal. Macroscopic
examination of the animals did not reveal any test substance related
abnormalities. The oral LD50 value of D-C16 in Wistar rats was
established to exceed 2000 mg/kg body weight. According to the OECD 423
test guideline, the LD50 cut-off value was considered to exceed 5000
mg/kg body weight. Based on these results, D-C16 does not have to be
classified and has no obligatory labelling requirement for acute oral
toxicity according to the Globally Harmonized System of Classification
and Labelling of Chemicals (GHS) of the United Nations (2011) (including
all amendments) and Regulation (EC) No 1272/2008 on classification,
labelling and packaging of substances and mixtures (including all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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