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EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 March 1983 to 6 May 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- not applicable
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- EC Number:
- 255-255-2
- EC Name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- Cas Number:
- 41198-08-7
- Molecular formula:
- C11H15BrClO3PS
- IUPAC Name:
- 4-bromo-2-chlorophenyl ethyl (propylsulfanyl)phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Analytical verification of doses or concentrations:
- no
- Details on mating procedure:
- Rabbits were paired 1:1, with does placed in the buck's cage. When mating was observed the dose was weighed and lutenizing hormone was injected into the marginal ear vein. The doe was then returned to her cage.
- Duration of treatment / exposure:
- GD 6 -18/ oral gavage
- Frequency of treatment:
- daily
- Duration of test:
- 12 days
- No. of animals per sex per dose:
- 16 females
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 90 mg/kg bw/day (nominal)
- Based on:
- not specified
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 175 mg/kg bw/day (nominal)
- Based on:
- not specified
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 175 mg/kg bw/day
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: the test material was devoid of embroyonic or teratogenic activity in New Zealand White rabbits up to a maximum dose of 175 mg/kg/day
Overall developmental toxicity
- Developmental effects observed:
- no
- Lowest effective dose / conc.:
- 175 mg/kg bw/day
- Treatment related:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In conclusion, CGA 15324 technical was devoid of embroyonic or teratogenic activity in New Zealand White rabbits up to a maximum dose of 175 mg/kg/day. The maternal NOAEL was deemed to be 90 mg/kg/day due to reduced food consumption at 175 mg/kg/day.
- Executive summary:
The embryotoxic and teratogenic potential of CGA-15324 Technical was evaluated in albino rabbits. The test material was administered by gavage to inseminated female rabbits at dose levels of 0, 30, 60, 90 or 175 mg/kg/day from day 6 through to 18 of gestation. Each dose level consisted of 16 does. On GD 30 does were euthanised and laparohysterectomies were performed.
Maternal mortality was observed in the control (1); 60 (2) and 175 (9 does) mg/day groups. Changes in clinical signs were observed in all groups. These changes were observed consistently in the high dose group and consisted of anorexia (reduced food intake), diarrhoea,soft stool and oral and perianal discharges.
The lesions observedin the animals that died on the study were necropsied, primarily involved yellow discolouration of the mesentery in the gastric region and pinpoint haemorrhages in the stomach. No gross lesions were observed in any of the animals suriviving to laparohysterectomy.
No statisitically significant differences were observed between the control and treated groups for bodyweight gain during gestation, maternal mortality, or mean copora lutea. Because the 175 mg/kg/day group constituted the maternal multi-dose LD50, the mortality observed in the high dose group was considered biologically relevant.
No significant differences were observed for the following measures of prenatal toxicity: mean number of implantations; litter size; foetal body weight; or embryolethality. No significant differences were detected between the control and treated groups for malformations or variations.
In conclusion, CGA 15324 technical was devoid of embroyonic or teratogenic activity in New Zealand White rabbits up to a maximum dose of 175 mg/kg/day. The maternal NOAEL was deemed to be 90 mg/kg/day due to reduced food consumption at 175 mg/kg/day.
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