Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 October 2005 to 10 November 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF 12 Nouan 8147 (2000)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- EC Number:
- 255-255-2
- EC Name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- Cas Number:
- 41198-08-7
- Molecular formula:
- C11H15BrClO3PS
- IUPAC Name:
- 4-bromo-2-chlorophenyl ethyl (propylsulfanyl)phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hour exposure
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 animals/sex/gp
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- other: no deaths observed
Any other information on results incl. tables
Individual body weights and doses are presented in Table 1. Individual cage-side and necropsy observations are presented in Tables 2 and 3, respectively.
All animals survived, gained body weight, and appeared active and healthy during the study. Apart from dermal irritation (erythema and edema) noted at the dose site of four females between Days 1 and 2, there were no other signs of gross toxicity, adverse pharmacologic effects or abnormal behavior. No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
Table 7.2.3-1: Individual bodyweights/weight gains and doses
Animal No. |
Sex |
Body Weight (g) |
Dose# ml |
||||
Day 0 Weight |
Day 7 Weight |
Gain* |
Day 14 Weight |
Gain* |
|||
6089 |
M |
220 |
253 |
33 |
316 |
96 |
0.29 |
6090 |
M |
241 |
261 |
20 |
338 |
97 |
0.32 |
6091 |
M |
247 |
269 |
22 |
322 |
75 |
0.33 |
6092 |
M |
243 |
273 |
30 |
356 |
113 |
0.33 |
6093 |
M |
246 |
277 |
31 |
347 |
101 |
0.33 |
6094 |
F |
190 |
211 |
21 |
236 |
46 |
0.25 |
6095 |
F |
178 |
190 |
12 |
233 |
55 |
0.24 |
6096 |
F |
191 |
204 |
13 |
241 |
50 |
0.26 |
6097 |
F |
196 |
210 |
14 |
247 |
51 |
0.26 |
6098 |
F |
189 |
207 |
18 |
242 |
53 |
0.25 |
* - Body weight gain from Day 0.
# -The test substance was administered as received. Specific Gravity – 1.487 g/ml.
Table 7.2.3-2: Individual cage-side observations
Animal Number |
Findings
|
Day of Occurrence
|
MALES 6089 – 6093 |
Active and healthy |
0-14 |
FEMALES 6094, 6096, 6097 |
Active and healthy Erythema / oedema present at dose site |
0-14 1-2 |
6095 |
Active and healthy |
0-14 |
6098 |
Active and healthy Erythema / oedema present at dose site |
10-14 1 |
Table 7.2.3-3: Individual necropsy observations
Animal Number |
Tissue |
Findings
|
MALES 6089 – 6093 |
All tissues and organs |
No gross abnormalities |
FEMALES 6094 - 6098 |
All tissues and organs |
No gross abnormalities |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the single dose acute dermal LD50 of Profenofos Technical is greater than 2000 mg/kg of body weight in male and female rats.
- Executive summary:
An acute dermal toxicity test was conducted with rats to determine the potential for Profenofos Technical to produce toxicity from a single topical application.
Two thousand milligrams of the test substance per kilogram of body weight was applied to the skin of ten healthy rats for 24 hours. The animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days. Body weights were recorded prior to application and again on Days 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice.
All animals survived, gained body weight and appeared active and healthy during the study. Apart from dermal irritation (erythema and edema) noted at the dose site of four females between Days 1 and 2, there were no other signs of gross toxicity, adverse pharmacologic effects or abnormal behavior. No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
Under the conditions of this study, the single dose acute dermal LD50 of Profenofos Technical is greater than 2000 mg/kg of body weight in male and female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.