Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: literature value
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- NA
- GLP compliance:
- not specified
- Transformation products:
- not specified
- pH:
- 5
- Temp.:
- 20 °C
- DT50:
- 93 d
- Type:
- not specified
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 14.6 d
- Type:
- not specified
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 5.7 h
- Type:
- not specified
- Executive summary:
The 15th edition of The Pesticide Manual gives the following information on the stability of Profenofos:
Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions.
DT50 values calculated at 20 degree C give values of 93 days (pH5), 14.6 days (pH7) and 5.7 hours (pH9).
- Endpoint:
- hydrolysis
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- The hydrolysis of profenofos was estimated using the HYDROWIN program in EPISUITE based on the structure of profenofos which is inputted in the form of SMILES notation.
- GLP compliance:
- not specified
- Remarks:
- Not applicable
- Transformation products:
- not specified
- pH:
- 5
- DT50:
- 3.064 d
- pH:
- 7
- DT50:
- 2.98 d
- pH:
- 9
- DT50:
- 19.01 h
- pH:
- 10
- DT50:
- 2.477 h
- Conclusions:
- The half-life of profenofos in is estimated to be 2.98 days at pH 7, slightly longer in slightly acidic conditions (3.064 days at pH5) and much shorter in alkaline conditions (2.477 hours at pH 10).
- Executive summary:
The hydrolytic stability of profenofos was estimated using EPISUITE after inputting the structure in the form of SMILES notation.
Results show that degradation of profenofos is quicker in alkaline conditions than in neutral or slightly acidic conditions.
The half-life at pH7 is estimated to be 2.98 days.
Referenceopen allclose all
Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions.
Description of key information
Half-life of profenofos estimated with EPISUITE with a DT-50 of 2.98 days at pH 7.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 2.98 d
- at the temperature of:
- 20 °C
Additional information
The hydrolytic stability of profenofos was estimated using EPISUITE after inputting the structure in the form of SMILES notation.
Results show that degradation of profenofos is quicker in alkaline conditions than in neutral or slightly acidic conditions.
The half-life at pH 7 is estimated to be 2.98 days.
The 15th edition of The Pesticide Manual gives the following information on the stability of Profenofos: Relatively stable under neutral and slightly acidic conditions. Unstable under alkaline conditions. DT50 values calculated at 20 degree C give values of 93 days (pH 5), 14.6 days (pH 7) and 5.7 hours (pH 9).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.