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EC number: 258-904-8
CAS number: 53988-10-6
In 2 limited studies Vulkanox MB2 (methyl-2-mercaptobenzimidazole) was tested for skin irritation/corrosion and eye irritation. The test substance was found to be not irritating to the skin and not irritating to the eye. Although the eye irritation test is limited with respect to dose (50 mg instead of 100 mg), due to the absence of any effect the study is reliable.Additionally, a sin irritation/corrosion study and an eye irritation study with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS 61617-00-3) as a surrogate for 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione (CAS 53988-10-6) were also negative.
The test substance proved to be not irritating to the skin
The test substance proved to be not irritating to the eye
A dose of 50 mg of the test substance was administered into one eye of
one male and one female adult New Zealand White rabbit (3-4 kg) for an
exposure period of 24 hours. Then the treated eyes were rinsed with
sterile water. The contralateral eye remained untreated and served as a
control. The eyes were examined and the grade of the ocular reaction was
recorded until day 7 according to Draize et al. (J. Pharmacol. Exp.
Ther. 82, 377-390 (1944)).
The test substance was not irritating to the eye (score = 0 at any time
The test substance was tested in a 24 h skin irritation/corrosion test
in rabbits not conducted according actual guidelines. The test substance
(500 mg) was semi-occlusively applied once to the intact skin (inside a
rabbit ear) and remained there for 24 hours. The animals were observed
for 7 days after experiment. Mean value for erythema according to DRAIZE
was: 0.0; mean value for edema: 0.0. The test substance was found to be
The test substance was tested in a 24 h eye irritation test in rabbits.
The test substance (50 mgl) was administered into one eye of 2 rabbits
(the other eye remained untreated and served as control). The substance
was washed out after 24 hours with sterile water.
The animals were observed for 7 days after experiment.
The test substance was found to be not irritating to eye.
mean value for erythema = 0, mean value for edema = 0
On the basis of this data a classification is not justified
mean values for cornea opacity (0); mean values for iris inflammation
mean values for conjunctivae reddening (0), mean values for conjunctivae
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