Registration Dossier
Registration Dossier
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EC number: 206-114-9 | CAS number: 302-01-2
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: migrated dataset
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: administration of the testsubstance not relevant for the human situation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Pathology and Toxicology of Repeated Doses of Hydrazine and 1,1-Dimethylhydrazine in Monkeys and Rats.
- Author:
- Patrick RL and Back KC
- Year:
- 1 965
- Bibliographic source:
- Ind. Med. Surg. 34, 430-435.
- Reference Type:
- other: abstract
- Title:
- Hydrazine
- Author:
- Patrick RL
- Year:
- 1 964
- Bibliographic source:
- Technical Documentation Report No AMRL-TOR-64-43
Materials and methods
- Principles of method if other than guideline:
- Method: other: migrated dataset
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS
: migrated dataset
TS-Freetext:
practical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other:
- Duration of treatment / exposure:
- up to 5 weeks
- Frequency of treatment:
- once daily, 5 days per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 or 20 mg/kg
- No. of animals per sex per dose:
- migrated dataset
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: no
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- >= 10 - <= 20 mg/kg bw/day
- Sex:
- male
- Basis for effect level:
- other: rat
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Dose-dependent weight loss; mortality in high dose group 10/25 (8-21 injection), signs of toxicity were weakness, lethargy, lowered food intake, partial epilation, convulsions in 2 rats; in both groups hematocrit value lowest after 13 injections; serum glutamic oxaloacetic transaminase tended to increase after 3 injections; pulmonary congestion and edema in 4 rats and hepatic lipidosis in 7 rats of the high dose group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
