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EC number: 290-754-9
CAS number: 90218-76-1
Acute skin and eye irritation studies with
1,2,4 -Benzenetricarboxylic acid, decyl octyl ester have been conducted
In the key study 1,2,4-Benzenetricarboxylic
acid, mixed decyl and octyl triesters was slightly irritating to the
the effects in the skin were fully
reversible within 8 days. In a supporting study no skin irritation was
In the key study to test the acute irritant
effect of 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl
triesters on the eyes and mucosa, 0.1 cm³ of the liquid test substance
was administered into the conjunctival sac of one eye of each of three
male rabbits. After exposure for 72 hours, the eyes were washed out with
warm physiological saline. The test was carried out according to OECD
guideline 405 (12 May 1982).
The test showed that administration of
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters caused
no irritation reactions at cornea and iris. At the conjunctivae 1 hour
after application circumcorneal injections in all animals and mild
discharge in one animal were observed, after 24 hours all animals were
free of symptoms.
The following mean values, based on the
results from the 24 -, 48 - and 72 hour-readings were calculated:
Cornea opacity: 0.0
Iris lesion: 0.0
Redness of conjuntiva: 0.0
Oedema of conjunctiva: 0.0
Based on the result of this study
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters was
judged to be non irritating to eyes and mucosa.
In a supporting study the test item produced
a maximum group mean score of 6.7 (at 1 hour observation) was slightly irritant.
The results of the skin and eye
irritating studies show that 1,2,4-Benzenetricarboxylic acid,
mixed decyl and octyl triesters does not warrant classification
according to Regulation
(EC) No 1272/2008.
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