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EC number: 290-754-9
CAS number: 90218-76-1
Table #: Irritant/corrosive response
data for each animal at each observation time of each animal from the
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Maximum average score (including area affected, max 110)
Average time (unit) for reversion
*) Reversibility: c. = completely
reversible; n.c. = not completely reversible; n. = not reversible
To test the acute
irritant effect of 1,2,4-Benzenetricarboxylic acid, mixed decyl and
octyl triesters on the eyes and mucosa, 0.1 cm³ of the liquid test
substance was administered into the conjunctival sac of one eye of each
of three male rabbits. After exposure for 72 hours, the eyes were washed
out with warm physiological saline. The test was carried out according
to OECD guideline 405 (12 May 1982).
The test showed that administration of
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters caused
no irritation reactions at cornea and iris. At the conjunctivae 1 hour
after application circumcorneal injections in all animals and mild
discharge in one animal were observed, after 24 hours all animals were
free of symptoms.
The following mean values, based on the
results from the 24 -, 48 - and 72 hour-readings were calculated:
Cornea opacity: 0.0
Iris lesion: 0.0
Redness of conjuntiva: 0.0
Oedema of conjunctiva: 0.0
Based on the result of this study
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters was
judged to be non irritating to eyes and mucosa.
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