Registration Dossier
Registration Dossier
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EC number: 248-145-0 | CAS number: 26966-75-6
Endpoint summary
Administrative data
Description of key information
The no observed adverse effect level (NOAEL) was 50 mg/kg body weight/day for 28 days in male and female rats.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
Additional information
In a modern, reliable guideline study, the oral administration of ortho-TDA by gavage over a period of 28 days revealed substance-related adverse findings in animals of both sexes at 250 mg/kg bw/day. There were temporary clinical signs of toxicity at this dose, with reduced body weight gain. Also at this dose findings of increased liver weight and clinical chemistry changes in both sexes indicated an effect on the liver which was identified as target organ. The no observed adverse effect level (NOAEL) under the conditions of the present study was 50 mg/kg body weight/day in male and female rats.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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