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EC number: 204-137-9
CAS number: 116-37-0
In the first mutation assay no cytotoxicity was apparent at
concentrations up to and including 100 µg/mL; total cell death was
observed at 150 µg/mL (-S9). In the second test, no cytotoxicity was
observed up to and including 150 µg/mL. In the supplementary assay,
reduced plating efficiency was observed at and above 130 µg/mL (-S9); in
the presense of S9 toxicity was observed at and above 160 µg/mL.
No increases in mutation frequencies (or mutant colony numbers) were
observed in Dianol 320 treated culteres, both in the absence and
presence of S9.
(BPA+2PO) was examined for mutagenic potential by measuring its
ability to induce mutation in Chinese hamster (V79) cells at the
hypoxanthine-guanine-phosphoribosyl transferase (HGPRT) locus. Under the
experimental conditions of the test, 4,4’-Isopropylidenediphenol,
propoxylated (BPA+2PO) showed no evidence of mutagenic activity at
the HGPRT gene locus, when cells were treated in the absence or presence
of S-9 mix. The sensibility of the assay system was proven by the
observed responses to known mutagens.
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