Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-137-9
CAS number: 116-37-0
An OECD 408 compliant 90 -day study in rat via oral route with
BPA-2PO resulted to aNOAEL of 180 mg/kg/day. The corrected 8 hr
inhalation NOAEC for workers is NOAEL (180) * 1.76 *1 *1.4 mg/m3 =
- 1 : factor 1 for route extrapolation from oral to inhalation is
applied However, it is worthy to note that due to very low vp (<0.0015
Pa), exposure is only possible as aerosol.
If any exposure via inhalation does occur, this can only be in the
form of larger droplets, as the use does not include fine spraying or
Droplets will deposit mainly on upper airways, and will be
subsequently swallowed following mucociliary transportation to pharynx.
This results to no principal differences in absorption compared to oral
route. Thus, apply a factor 1 is still a very conservatism approach.
- 1.4 : correction for differences between human and experimental
exposure condition (workers)
- 1.76 : correction for differences in respiratory volume
point: NOAEL of 180 mg/kg bw/day in a sub-chronic oral toxicity study in
rats. As oral absorption is considered to be 100 % and dermal absorption
is considered to be 10%, a factor of 10 for dermal absorption will be
applied. Thus, the modified dose descriptor starting point is 1800 mg/kg
Starting point: NOAEL of 180 mg/kg bw/day in a sub-chronic oral
toxicity study in rats.
Corrected inhalatory NOAEC = 180 * (1/1.15)* (1) = 156.52 mg/m3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again