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EC number: 204-137-9
CAS number: 116-37-0
An acute oral and dermal toxicity studies with rats are available, both showing LD50 values >2000 mg/kg bw.
Test substance (g/kg)
Acute oral toxicity:
an acute oral toxicty study with rats, 5 animals/sex were exposed to
different concentrations of the substance, mortality occured from 3
hours till 3 days after treatment. Within a few hours after dosing
sluggishness and diarrrhoea were observed; several rats lost
consciousness and died. Survivors recovered after 3 days. The
LD50 was calculated to be 2.76 g/kg bw (LD50 between 2.75 g/kg bw (30%
mortality) and 3.30 g/kg bw (90% mortality)).
Acute dermal toxicity:
a reliable acute dermal toxicity study in rat, performed according to
OECD guidelines, the LD50 is >2000 mg/kg bw. Piloerection and
chromodacryorrhoea was shown by one male on Day 1. No clinical signs
were shown by the other animals. No other effects were observed and no
mortalities occurred at 2000 mg/kg bw.
Based on the results observed in the acute
toxicity studies with rats, 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2
–ol does not have to be classified and has no
obligatory labelling requirement for acute oral and dermal toxicity
according to the:
- Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) of the United Nations
- Regulation (EC) No 1272/2008 on
classification, labelling and packaging of substances and mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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