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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The authors tested the hydrolysis of benzal chloride in light and heavy water following a methodology described by Robertson R.E. in 1955 (Canadian Journal of Chemistry, 33, 1536). GLP standards are not specified and the study is considered Klimisch 2e as it is well documented, meets generally accepted scientific principles and is acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Solvolysis in hydrogen and deuterium oxide
Author:
Laughton P.M. and Robertson R.E.
Year:
1959
Bibliographic source:
Canadian Journal of Chemistry, 37: 1491 - 1496

Materials and methods

Principles of method if other than guideline:
Method of measuring kinetic rates was similar to the one used previously (Robertson R.E., 1955, Canadian Journal of Chemistry, 33, 1536)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): PhCHCl2

No more data available
Radiolabelling:
not specified

Study design

Analytical monitoring:
not specified

Results and discussion

Transformation products:
not specified
Dissipation DT50 of parent compoundopen allclose all
Temp.:
29.98 °C
DT50:
3.89 min
St. dev.:
0.03
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: hydrolysis in hydrogen oxide
Temp.:
29.98 °C
DT50:
5.83 min
St. dev.:
0.01
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: hydrolysis in deuterium oxide

Any other information on results incl. tables

- The hydrolysis rate constants were

for hydrogen oxide: kH20X 105sec-1: 297 +/- 2

for deuterium oxide: kD20X 105sec-1: 198 +/- 0.4

- The half-life values were calculated using the formula: t1/2 = ln 2 / (kH20)

- kD20 / kH2O: 0.66

No more data available

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The authors tested the hydrolysis of benzal chloride in light and heavy water following a methodology described by Robertson R.E. in 1955 (Canadian Journal of Chemistry, 33, 1536). In the conditions tested the hydrolysis rate of the test substance was 297 +/- 2 (kH20X 10E5 sec-1) for hydrogen oxide and 198 +/- 0.4 (kD20X 10E5 sec-1) for deuterium oxide. Using the formula t1/2 = ln 2 / (kH20) the half-life was calculated which is 3.89 min in hydrogen oxide and 5.83 min in deuterium oxide. The relation of rate ratios (kD20 / kH2O) is 0.66.
Executive summary:

The authors tested the hydrolysis of benzal chloride (CAS n° 98 -87 -3) in light and heavy water following a methodology described by Robertson R.E. in 1955 (Canadian Journal of Chemistry, 33, 1536). In the conditions tested the hydrolysis rate of the test substance was 297 +/- 2 (kH20X 10E5 sec-1) for hydrogen oxide and 198 +/- 0.4 (kD20X 10E5 sec-1) for deuterium oxide at 29.98°C. Hence the half life values for the test substance in hydrogen oxide and deuterium oxide are 3.89 min and 5.83 min respectively. The relation of rate ratios (kD20/kH20) is 0.66.

GLP standards are not specified and the study is considered as reliable with restrictions as it is well documented, meets generally accepted scientific principles and is acceptable for assessment.