Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study is insufficiently described as sampling and quantification are not known. Therefore, this study should be considered as not assignable due to insufficient documentation.

Data source

Reference
Reference Type:
publication
Title:
Occupational exposure to benzyl chloride and benzal chloride due to contaminated butyl benzyl phtalate
Author:
Rittfeld L.M.
Year:
1983
Bibliographic source:
Scand. J. Work Environ Health, 9, 367-368.

Materials and methods

Type of study / information:
Occupational exposure to benzal chloride
Endpoint addressed:
not applicable
Principles of method if other than guideline:
Exposure levels to benzal chloride have been assessed in industrial PVC flooring processors plants
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): benzal chloride
No further data

Method

Details on study design:
Exposure levels of benzal chloride were measured in air of manufacturing plant of PVC floorings near manufacturing lines.
Exposure assessment:
measured

Results and discussion

Results:
0.15 mg/m³ near the manufacturing lines of PVC floorings was detected and 0.2 mg/m³ in air near surface film manufacturing lines was detected. Benzal chloride was a contaminant of butyl benzyl phthalate used as a plasticizer in PVC floorings. Benzal chloride was also detected in the atmosphere over a 10-day old vinyl floor tile. Furthermore, at room temperature, the emission rate of benzal chloride from PVC floorings was calculated to be about 0.01 mg per hour and square meter.

Applicant's summary and conclusion

Conclusions:
In this study, the authors found that workers in a PVC floorings plant were exposed to 0.15 mg/m³ or 0.2 mg/m³ near processing machines of benzal chloride as a contaminant of butyl benzyl phthalate.
Executive summary:

In this study, exposure levels of benzal chloride were measured in air of manufacturing plant of PVC floorings near manufacturing lines after some cases of occupational irritation were noted.

0.15 mg/m³ of benzal chloride near the manufacturing lines of PVC floorings was detected and 0.2 mg/m³ in air near surface film manufacturing lines was detected. Benzal chloride was determined to be a contaminant of butyl benzyl phthalate used as a plasticizer in PVC floorings. Benzal chloride was also detected in the atmosphere over a 10-day old vinyl floor tile. Furthermore, at room temperature, the emission rate of benzal chloride from PVC floorings was calculated to be about 0.01 mg per hour and square meter.

However, there is no mention of the quantification method neither on the sampling method. Results are not sufficiently described and specific context of the occupational exposure is not clear. Therefore, this study should be considered as not assignable ude to insufficient documentation.