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EC number: 242-893-1
CAS number: 19223-55-3
In a Guinea-Pig Maximisation Test performed according to OECD No.
406 test guideline, Cocamidopropyl hydroxysultaine as a 42% solution was
tested for its skin sensitising potential in Pirbright guinea pigs.
A preliminary test on two animals using the test solution at 100%
showed that this concentration was appropriate for topical application.
For the main test, 20 animals were applied the vehicle (deionised water)
only (control group) and 20 other animals were applied the test
substance. For the induction phase, animals received an intradermal
injection of the test substance at 10% in deionised water or in Freund’s
Complete Adjuvant (FCA) emulsion. One week later, a second induction was
performed by a topical application of the test solution at 100%. Two
weeks after the topical induction phase, challenge was performed by
applying the test substance at 100% topically under occlusive conditions
for 24 hours. Observation and grading of skin reactions was performed 24
and 48 hours after patch removal to assess potential sensitisation.
No skin reaction and therefore no sign of sensitisation was
observed 24 and 48 hours after the challenge in any animal (control or
Therefore, under the conditions of this test, Cocamidopropyl
hydroxysultaine as a 42% solution is not considered as a skin sensitiser
according to the criteria of Directive 67/548/EEC (DSD) or Regulation
(EC) 1272/2008 (CLP).
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