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EC number: 242-893-1
CAS number: 19223-55-3
(µL test solution)
Ratio vs. controls
First experiment: Summary of
numbers of revertants per plate
Cocamidopropyl hydroxysultaine, as a 50% aqueous solution, was tested in
a bacterial reverse mutation (Ames) test using the Salmonella
typhimurium TA1535, TA1537, TA1538, TA98 and TA100 strains. The
bacterial strains were exposed on minimal agar plates (using a plate
incorporation method) to a range of concentrations up to 20 µL of test
solution per plate, both in the presence or absence of an exogenous
metabolic activation system, consisting of S9 mix from Aroclor 1254
-induced rat liver. Two independent experiments were performed in
In this Ames test, no significant increase in the mean number of
revertants over the respective vehicle controls was observed in any of
the bacterial strains tested, either in the presence or in the absence
of metabolic activation, up to 0.2 or 0.6 µL test solution/plate
depending on the strain. Cyotoxic effects were observed at higher dose
Under the conditions of this assay, Cocamidopropyl hydroxysultaine, as a
50% aqueous solution, was not mutagenic up to cytotoxic concentrations.
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