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EC number: 242-893-1
CAS number: 19223-55-3
A Repeated Insult Patch Test using semioccluded patches was carried out
on 54 male and female healthy volunteers with Mackam LSB50 diluted at
12% in distilled water.
The induction phase consisted in 9 topical applications (3
applications/weeks) of the test item in the upper back region between
the scapulae. Approximately two weeks after the final Induction patch
application, a Challenge patch was applied to a virgin test site
adjacent to the original Induction patch site. The patch was removed and
the site scored 24 and 48 hours post-application.
The test item was non-irritating following a single application for 24
hours (erythema score = 0 in all subjects, absence of any dermal
There was no indication of contact sensitization.
Repeated dermal application of a 12% aqueous solution of Mackam LSD50 to
54 healthy human volunteers under semiocclusive conditions did not
result in any skin reaction indicative of irritation or sensitization.
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