Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide
  • IUPAC name: [phenyl(2,4,6-trimethylbenzoyl)phosphoryl](2,4,6-trimethylphenyl)methanone
  • Other names
EC / List no.:
423-340-5
CAS no.:
162881-26-7
Index number:
015-189-00-5
Molecular formula:
C26H27O3P
SMILES:
CC1=CC(C)=C(C(=O)P(=O)(C(=O)C2=C(C)C=C(C)C=C2C)C2=CC=CC=C2)C(C)=C1
InChI:
InChI=1S/C26H27O3P/c1-16-12-18(3)23(19(4)13-16)25(27)30(29,22-10-8-7-9-11-22)26(28)24-20(5)14-17(2)15-21(24)6/h7-15H,1-6H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
17
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may cause long lasting harmful effects to aquatic life and may cause an allergic skin reaction.

Breakdown of all 925 C&L notifications submitted to ECHA

Aquatic Chronic 4 H413 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Skin Sens. 1A H317
Skin Sens. 1B H317
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 19 active registrations under REACH, 1 Joint Submission(s) and 7 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 - 1 000 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance can be found in complex articles, with no release intended: vehicles. This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), wood (e.g. floors, furniture, toys) and plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: inks and toners, coating products, adhesives and sealants, fillers, putties, plasters, modelling clay, paper chemicals and dyes, polymers and finger paints.

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: wood and wood products, pulp, paper and paper products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: inks and toners, coating products, polymers, adhesives and sealants, fillers, putties, plasters, modelling clay, paper chemicals and dyes and finger paints.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, laboratory work, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: coating products, inks and toners, adhesives and sealants, polymers, fillers, putties, plasters, modelling clay, paper chemicals and dyes and finger paints.

This substance is used in the following areas: printing and recorded media reproduction, building & construction work and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: wood and wood products, pulp, paper and paper products, fabricated metal products, furniture, rubber products, electrical, electronic and optical equipment, machinery and vehicles, textile, leather or fur and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, treatment of articles by dipping and pouring, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and industrial spraying.

Release to the environment of this substance can occur from industrial use: in the production of articles and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: contaminated work clothing should not be allowed out of the workplace; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. Take off contaminated clothing and wash it before reuse. If skin irritation or a rash occurs: get medical advice/attention. Follow specific treatment (see label). If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Agfa-Gevaert N.V., Septestraat 27 2640 Mortsel Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Solutions Limited, 27 Old Gloucester Street WC1N 3AX London United Kingdom
  • Chemservice S.A. (8LF5), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • COSMO GROUP Sp. z o.o. Sp. k., Jasielska 10a 60-476 Poznań Poland
  • GEELIO Umwelttechnologie GmbH, Hans-Thoma-Strasse 25 D-68163 Mannheim Germany
  • GEELIO Umwelttechnologie GmbH, Pfälzer Ring 25-29 D-68766 Hockenheim Baden-Würtemberg Germany
  • GEELIO Umwelttechnologie GmbH, Hans-Thoma-Strasse 25 68163 Mannheim Germany
  • IGM Resins B.V., Gompenstraat 49 5145 RA Waalwijk Netherlands
  • IGM Resins Italia S.r.l, Via Vincenzo Monti, 8 20123 Milano Italy
  • Intercoat Specialties, SL, Verge del Pilar, 6 08185 Molins de Rei Barcelona Spain
  • Lambson Limited, Clifford House York Road LS22 7NS Wetherby West Yorkshire United Kingdom
  • Nesperta sp. z o.o. , Rejtana 12 A 62-030 Luboń Poland
  • RAHN (3), Hahnstrasse 70 D-60528 Frankfurt am Main Germany
  • RAHN NL B.V. (30), Westplein 11 3016BM Rotterdam Netherlands
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland

Other names

  • -
  • Bis(2,4,6-trimethylbenzoyl) Phenylphosphine Oxide
  • CH03850
  • Methanone, 1,1'-(phenylphosphinylidene)bis[1-(2,4,6-trimethylphenyl)-
  • Methanone,1,1'-(phenylphosphinylidene)bis[1-(2,4,6-trimethylphenyl)]-
  • phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxid
  • Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide
  • Phenylbis(2,4,6-trimethylbenzoyl)phosphine Oxide
  • Phosphine oxide, phenylbis(2,4,6-trimethylbenzoyl)-
  • Speedcure BPO
  • [phenyl(2,4,6-trimethylbenzoyl)phosphoryl](2,4,6-trimethylphenyl)methanone
  • [phenyl-(2,4,6-trimethylbenzoyl)phosohoryl]-(2,4,6-trimethylphenyl),ethanone
  • [Phenyl-(2,4,6-trimethylbenzoyl)phosphoryl]-(2,4,6-trimethylphenyl)methanone
  • Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide
  • CGI 819
  • Chivacure 789
  • GENOCURE* BAPO
  • IHT-PI 920
  • Irgacure 819
  • Omnirad 808
  • PI 808
  • Speedcure BPO

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 10 studies submitted
  • 10 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [10]
C Form
Powder (80%), Crystalline (20%) [10]
C Odour
Odourless (50%), Other (38%), Slight (13%) [8]
C Substance type
Organic (100%) [10]

Type of Study provided
Studies with data
Key study 8 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 10 studies submitted
  • 10 studies processed
R Melting / freezing point
127 - 131.4 °C @ 101.3 kPa [10]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Melting / freezing point at 101 325 Pa
127 - 131.4 °C

Boiling point

Study results
  • 10 studies submitted
  • 8 studies processed
R Boiling point
168 °C @ 101.3 kPa [8]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
168 °C

Density

Study results
  • 10 studies submitted
  • 10 studies processed
R Density
1.19 g/cm³ @ 21 °C [2]
R Relative density
1.19 @ 21 °C [8]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
Relative density at 20°C
1.19

Vapour pressure

Study results
  • 10 studies submitted
  • 10 studies processed
R Vapour pressure
0 - 0 Pa @ 20 - 25 °C [19]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 13 studies submitted
  • 13 studies processed
R Log Pow
4.65 - 5.8 @ 20 - 22 °C and pH 7 - 8.3 [13]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 5 summaries processed
Log Kow (Log Pow)
5.77 - 5.8 @ 22 °C

Water solubility

Study results
  • 10 studies submitted
  • 10 studies processed
R Water solubility (mass/vol.)
100 µg/L @ 20 °C and pH 7.5 [10]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
Water solubility
100 µg/L @ 20 - 21 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 10 studies submitted
  • 7 studies processed
R Surface tension
70.7 - 71.4 mN/m @ 100 - 100 000 µg/L and 20 °C [7]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Surface tension at 20 °C
71.1 mN/m @ 0.1 mg/L

Flash point

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 5
Sci. unjustified 3
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 10 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
131.4 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Autoflammability / self-ignition at 101 325 Pa
131.4 °C

Flammability

Study results
  • 17 studies submitted
  • 8 studies processed
C Interpretation of results
Non flammable (100%) [8]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 7
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Flammability
Non flammable (75%), Not classified (25%)

Explosiveness

Study results
  • 10 studies submitted
  • 10 studies processed
C Interpretation of results
Non-explosive (100%) [10]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Oxidising
No (80%), Non oxidising (20%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 6
Sci. unjustified 1
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 12 studies submitted
  • 5 studies processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [5]

Type of Study provided
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
5

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Koc at 20°C
3.85 - 7 079.46

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 8 summaries submitted
  • 8 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 90 - 1 000 ng/L (8)
Intermittent releases (freshwater) 800 - 1 000 ng/L (8)
Marine water 9 - 1 000 ng/L (8)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (8)
Sediment (freshwater) 64 - 712 µg/kg sediment dw (2)
Sediment (marine water) 6.4 - 712 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (8)
Hazard for Terrestrial Organism
Soil 12.8 - 20 000 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (8)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
LC50 (4 days) 90 µg/L [8]
LC50 (72 h) 90 µg/L [4]
LC50 (48 h) 90 µg/L [5]
LC50 (24 h) 90 µg/L [5]
LC0 (4 days) 90 µg/L [2]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
LC50 for freshwater fish
90 µg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
EC50 (48 h) 1.175 mg/L [10]
EC50 (24 h) 1.175 mg/L [7]
EC0 (48 h) 3.1 µg/L [2]
EC100 (48 h) 1.175 mg/L [7]
NOEC (48 h) 3.1 µg/L [9]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
EC50 / LC50 for freshwater invertebrates
1.175 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 8.1 µg/L [2]
LOEC (21 days) 8.1 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
EC50 (72 h) 260 µg/L [20]
NOEC (72 h) 260 µg/L [17]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 4 summaries processed
EC50 for freshwater algae
260 µg/L
EC10 or NOEC for freshwater algae
260 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 8 studies submitted
  • 8 studies processed
P/RResults
EC50 (3 h) 100 mg/L [3]
IC50 (3 h) 100 mg/L [5]
NOEC (3 h) 100 mg/L [5]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
100 mg/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC10 (56 days) 1 g/kg soil dw [2]
LC50 (28 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC10 (28 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 8 summaries submitted
  • 8 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7.84 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 7.84 mg/m³ repeated dose toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 3.33 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.93 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 3.92 mg/m³ repeated dose toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.5 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 1.67 mg/kg bw/day repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.5 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 1.67 mg/kg bw/day repeated dose toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 10 studies submitted
  • 10 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [10]
M/CInterpretations of results
Not classified [8]

Type of Study provided
oral
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 2
Other 4
dermal
  • 8 studies submitted
  • 8 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [7]
LD50 2 000 mL/kg bw (rat) [1]
M/CInterpretations of results
Toxicity Category V [1]

dermal
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 11
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 12 studies submitted
  • 10 studies processed
P/RResults
NOAEL (rat): 1 000 mg/kg bw/day [8]
NOEL (rat): 15 - 300 mg/kg bw/day [7]

Type of Study provided
Study data: oral
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 26 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 21 1
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 5
Other 2
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant