Registration Dossier
Registration Dossier
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EC number: 404-740-9 | CAS number: 115895-09-5
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
28d-NOEC = 1000 mg/kg dry weight sediment (nominal, emergence and development rate, Chironomus riparius, OECD 218)
28d-LOEC > 1000 mg/kg dry weight sediment (nominal, emergence and development rate, Chironomus riparius, OECD 218)
28d-EC50 > 1000 mg/kg dry weight sediment (nominal, emergence and development rate, Chironomus riparius, OECD 218)
28d-EC10 > 1000 mg/kg dry weight sediment (nominal, emergence and development rate, Chironomus riparius, OECD 218)
Key value for chemical safety assessment
Additional information
In a GLP study according to OECD guideline 218 conducted by Kuhn and Frank (2014), the effects of AF-366 on the development of sediment dwelling larvae of Chironomus riparius in a sediment-water system, exposed via spiked sediment, were tested. For this purpose, first instar larvae of Chironomus riparius were exposed for 28 days to assess the impact on full maturation of the larvae to adult midges. The larvae were exposed in a sediment-water system containing the test item at one limit concentration together with control and solvent control under defined conditions. No adverse effects were observed at a concentration of 1000 mg/kg dry weight used in this limit test. Thus, the 28 day NOEC for emergence rate was determined to be 1000 mg test item/kg dry sediment, with an associated LOEC of > 1000 mg test item/kg dry sediment. The NOEC for the development rate was determined to be 1000 mg test item/kg dry sediment, with an associated LOEC of > 1000 mg test item/kg dry sediment. The EC50 for the emergence rate was calculated to be > 1000 mg test item/kg dry sediment and > 1000 mg test item/kg dry sediment for development rate.
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