Registration Dossier
Registration Dossier
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EC number: 230-898-1 | CAS number: 7360-53-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test substance has a good water solubility (86.1 g/L at 20 °C). The experimentally determined log Pow of the test substance is <-3.6 (key study), the calculated partition coefficient log Pow using a QSAR-method is -2.5.
The acute oral toxicity is low (LD50>2000 mg/kg body weight). The LC50/4h is >2.51 mg/L and thus is higher than the highest technically producible concentration of respirable dust. However, severe toxic signs were noted at higher concentrations with higher particle sizes. The effects noted are attributed to local effects in the respiratory tract. This is supported by isolated findings in a combined repeated dose/developmental/reproductive screening study wherealterations were seen in the respiratory system (focal pneumonia, acute tracheitis). They were interpreted as effects of a severe local irritation of minute amounts of test substance preparation, deposited at gavage withdrawal in the oropharyngeal region, which were subsequently inhaled.
The target organ in a combined repeated dose/developmental/reproductive screening study was the stomach: In almost all high dosed females a proliferation of the limiting ridge of the stomach - the borderline between forestomach and glandular stomach - was noted. The proliferation of the limiting ridge is again interpreted as an indication for a local irritation, more likely of the forestomach than of the glandular stomach. The indication for a local irritation is also supported by the finding of inflammation of the submucosa.
The findings made in the acute and repeated dose toxicity studies, as well as the good water solubility and the low partition coefficient log Pow indicate a low bioavailability of the test substance.
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