Registration Dossier
Registration Dossier
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EC number: 264-439-1 | CAS number: 63741-10-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- The batch of Disperse Brown 27 (4852-1501) tested was a brown powder with a purity of 99.7 %
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 7.2
- Temp.:
- 35 °C
- pH:
- ca. 7
- Type:
- Pow
- Partition coefficient:
- > 16 000 000
- Temp.:
- 35 °C
- pH:
- ca. 7
- Details on results:
- Initially HPLC method ran without any pH buffer, under these conditions the test item was retained in the column, most likely due to being mainly present in its ionised form. Final conc of test item solution was 10 mg/L buffered to a pH of 7, POW >1.6x107, logPOW>7.2
- Conclusions:
- Initially HPLC method ran without any pH buffer, under these conditions the test item was retained in the column, most likely due to being mainly present in its ionised form. Final conc of test item solution was 10 mg/L buffered to a pH of 7, Pow >1.6x107, logPow>7.2
Reference
Initially HPLC method ran without any pH buffer, under these conditions the test item was retained in the column, most likely due to being mainly present in its ionised form. Final conc of test item solution was 10 mg/L buffered to a pH of 7, Pow >1.6x107, logPow>7.2
Description of key information
Initially HPLC method ran without any pH buffer, under these conditions the test item was retained in the column, most likely due to being mainly present in its ionised form. Final conc of test item solution was 10 mg/L buffered to a pH of 7, Pow>1.6x107, logPow>7.2
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.2
- at the temperature of:
- 35 °C
Additional information
Initially HPLC method ran without any pH buffer, under these conditions the test item was retained in the column, most likely due to being mainly present in its ionised form. Final conc of test item solution was 10 mg/L buffered to a pH of 7, Pow>1.6x107, logPow>7.2
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