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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study performed similar to OECD guideline 405, not under GLP, but acceptable basic data.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-ethylhexyl diphenyl phosphate

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 100% (undiluted)
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
3
Details on study design:
SCORING SYSTEM: according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1 hr
Score:
10.6
Reversibility:
fully reversible within: 48 hr
Remarks:
results per animals not available
Remarks on result:
other: scoring method not specified
Remarks:
results per animals not available
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hr
Score:
2
Reversibility:
fully reversible within: 48 hr
Remarks:
results per animals not available
Remarks on result:
other: scoring method not specified
Remarks:
results per animals not available
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hr
Score:
0
Reversibility:
other: not applicable
Remarks:
results per animals not available
Remarks on result:
other: scoring method not specified
Remarks:
results per animals not available
Irritant / corrosive response data:
It was noted that slight irritation of the rabbit eye was found. Given the report that only slight irritation was observed for both skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The reaction of the test material, 2-ethylhexyl diphenyl phosphate, on the rabbit eye was reported as slightly irritating. Given the report that only slight irritation was observed for both rabbit skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
Executive summary:

In a study, being conducted to a Draize design, test material, 2-ethylhexyl diphenyl phosphate, was applied undiluted to the eyes of three rabbits of unspecified strain. It was noted that slight irritation of the eye was found. Given the report that only slight irritation was observed for both rabbit skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.