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Environmental fate & pathways

Hydrolysis

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Description of key information

Hydrolysis can be a significant reaction of organic compounds in aqueous environmental compartments. Therefore, the hydrolysis of S-141 in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 was investigated at varying temperatures according to OECD method 111 under GLP.
The following half-lives were obtained:
DT 50 at pH 4 and 35 C was 219 days
DT 50 at pH 7 and 25 C was 102-109 days
DT 50 at pH 9 and 25 C was 40,8 days
Hydrolysis rate was directly proportional to an increase in pH and in temperature, which indicates that hydrolysis could be a dissipation route for S-141 in the environment.

Key value for chemical safety assessment

Half-life for hydrolysis:
109 d
at the temperature of:
25 °C

Additional information

Hydrolysis can be a significant reaction of organic compounds in aqueous environmental compartments. Therefore, the hydrolysis of S-141 in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 was investigated at varying temperatures according to OECD method 111 under GLP.

The following half-lives were obtained:

DT 50 at pH 4 and 35 C was 219 days

DT 50 at pH 7 and 25 C was 102-109 days

DT 50 at pH 9 and 25 C was 40.8 days

Hydrolysis rate was directly proportional to an increase in pH and in temperature, which indicates that hydrolysis could be a dissipation route for S-141 in the environment.