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EC number: 297-628-2
CAS number: 93685-80-4
data is being read across from the source study that tested
Hydrocarbons, C10-C12, isoalkanes,, <2% aromatics based on analogue read
In a dominant lethal assay, MRD-77-43 was
administered by vapor inhalation for six hours/day for five consecutive
days to male rats at dose levels of 300 and 900 ppm to test for
mutagenic potential. Included in the study was a negative (chamber
exposed) control group and a positive control group. The latter
received 0.5mg/kg of triethylenemelamine administered intraperitoneally
on a single day, two hours prior to mating. Each group contained 10
proven fertile rats. Following exposure, the males were mated with
unexposed females (two female rats were mated with each male rat per
week) for 6 consecutive weeks. The females were sacrificed 12 days
after the last day of cohabitation. Exposure of males to MRD-77-43
produced no adverse effects on mortality or body weight gain during the
post-treatment mating period. Overall, no treatment related effects were
observed on the number of pregnant females, number of implantations per
litter, number of live fetuses, number of dead implantations, and the
number of resoprtions. Exposures to male rats had no effect on their
ability to mate and impregnate females, and to produce live fetuses.
Based on these data, MRD-77-43 when administered by vapor inhalation to
male rats is not considered mutagenic by the dominant lethal test. This
finding does not warrant the classification of MRD-77-43 as a genotoxin
under the new Regulation (EC) 1272/2008 on classification, labeling, and
packaging of substances and mixtures (CLP) or under the Directive
67/518/EEC for dangerous substances and Directive 1999/45/EC for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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