Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 297-628-2
CAS number: 93685-80-4
data is being read across from the source study that tested
Hydrocarbons, C10-C12, isoalkanes,, <2% aromatics based on analogue read
A 90 -day subchronic study was conducted in
rats to assess the toxicity of Isopar M (MRD-89 -256). The test mixture
was administered by oral gavage at a dose of 0, 100, 500, or 1000 mg/kg,
7 days per week for a period of 13 weeks. The control animals received a
carrier (corn oil) dose and a satellite group was dosed at 1000 mg/kg, 7
days/week for 13 weeks and was then observed for reversibility,
persistence or delayed occurrence of toxic effects for 28 days
post-treatment. Observations were made as to the nature, onset,
severity, and duration of toxicological signs. No treatment-related
mortalities or clinical effects were observed. Animals in all dose group
exhibited an overall mean weight gain. Minimal changes were noted in the
hematology and serum chemistry values, however, all were considered to
be either within normal biological variation or not adverse effects. The
mean absolute and relative liver weights for both the 500 and 1000 mg/kg
dose groups (both sexes) were significantly greater than the
corresponding control values; however, these changes were found to be
reversible following the 28 day recovery period. Slight increases in
mean kidney weights were also noted in the 500 and 1000 mg/kg female
dose groups, however, these changes were not considered to be adverse
effects. All histopathological findings were minimal and no treatment
related adverse effects were noted. Based on the data recorded in this
study, the NOAEL for Isopar M is greater than 1000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again